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FLASH GENE

Symbol

HCRTR1

contributors: mct - updated : 07-07-2020

HGNC name	hypocretin (orexin) receptor 1
HGNC id	4848

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segment (7TM) receptor

HOMOLOGY

intraspecies

homolog to HCRTR2

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in the regulation of feeding behaviour
	couple to adenylyl cyclase regulation via multiple mechanisms
	orexin system modulates likely the formation and expression of fear memory via HCRTR1 in multiple pathways
	endogenous hypocretins acting on the HCRTR1 are required for the normal neural activity in the medial prefrontal cortex (mPFC), and thus might directly contribute cortical arousal and mPFC-dependent cognitive processes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	selectively binds the orexin A neuropeptide
	activation of HCRTR1 was found to attenuate agonist-activated OPRK1-mediated inhibition of cAMP production
	role of MRAP2 in the regulation of the orexin receptor 1 (HCRTR1)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   HCRTR1 blockade suppresses endogenous phasic dopamine signals, likely via actions at dopamine cell bodies

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous sleep   in contrast to GABA receptor agonists which induce sleep by generalized inhibition, HCRTR1 antagonists seem to facilitate sleep by reducing waking "drive"

ANIMAL & CELL MODELS

Ox1r(-/-) mice showed impaired freezing responses in both cued and contextual fear-conditioning paradigms