basic FUNCTION
| single strand DNA endonuclease, binding and hydrolyzing DNA contributing to the junction-specific endonuclease activity observed during DNA repair and recombination events |
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involved in transcription-coupled repair (TCR) of oxidative lesions |
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ERCC1/ERCC4 is a heterodimeric, structure-specific endonuclease that cleaves single-stranded/double-stranded DNA junctions and has roles in nucleotide excision repair (NER), interstrand crosslink (ICL) repair, homologous recombination, and possibly other pathways |
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NER factors ERCC5 and ERCC4 are essential for establishing CTCF-dependent chromatin looping between the promoter and terminator of the activated RARB2 gene |
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ERCC5 endonuclease promotes DNA breaks and DNA demethylation at promoters allowing the recruitment of CTCF and gene looping, which is further stabilized by ERCC4 |
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plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks |
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DCLRE1C and ERCC4-ERCC1 can also induce stalled DNA replication forks cleavage through non-epistatic pathways all along S and G2 phases of the cell cycle |
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MUS81 and ERCC4 are a subset of Structure-specific endonucleases (SSEs) that resolve aberrant replication structures |