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FLASH GENE
Symbol LSAMP contributors: mct/npt - updated : 09-06-2020
HGNC name limbic system-associated membrane protein
HGNC id 6705
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three Ig domains and a glycosyl-phosphatidylinositol anchor
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • immunoglobulin superfamily
  • plasticity-associated IgLON family neural adhesion molecules
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text the surface of somata and proximal dendrites
    basic FUNCTION
  • mediating selective neuronal growth and axon targeting
  • neuronal surface glycoprotein found in the cortical and subcortical regions of the limbic system
  • LSAMP and NTM promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions
  • function as a tumor suppressor gene in clear cell renal cell carcinoma
  • neuronal adhesive molecule, preferentially expressed in developing limbic system neuronal dendrites and somata (Must 2008)
  • might play a role in pathoaetiology of suicidal behaviour (Must 2008)
  • candidate tumor suppressor gene in osteosarcomas (Kresse 2009)
  • is a neural cell adhesion molecule involved in neurite formation and outgrowth
  • is involved in emotional and social operating systems by complex regulation of two alternative promoters
  • role for ADAM10-dependent shedding of cell surface LSAMP in promoting outgrowth from dorsal root ganglion cells (DRGs) neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interplay between LSAMP and NTM in regulating tissue homeostasis: the impact of NTM on cellular proliferation was dependent on LSAMP, and LSAMP appeared to be a positive regulator of apoptosis in the presence of NTM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in osteosarcoma (Yen 2009)
    tumoral   deletion    
    in osteosarcomas (Kresse 2009)
    tumoral     --over  
    of the LSAMP and TUSC7 genes in acute myeloid leukemia
    Susceptibility
  • to late-onset coronary artery disease (CAD)
  • to ulcerative colitis (UC)
  • to schizophrenia
    • Variant & Polymorphism SNP
  • increasing the risk of late-onset coronary artery disease (CAD)(Wang 2008)
  • SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for UC
  • significant allelic and haplotypic associations between LSAMP gene and schizophrenia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS