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FLASH GENE
Symbol FUT8 contributors: mct - updated : 20-10-2015
HGNC name fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HGNC id 4019
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides
  • relationship between FUT8 and the regulation of EGF receptor (EGFR)-trypsin-PAR-2 pathway in controlling cell growth
  • transfers fucose to the innermost N-acetylglucosamine unit of N-glycan chains
  • catalyzes the transfer of a fucose residue to N-linked oligosaccharides on glycoproteins via an alpha-1,6 linkage, leading to core fucosylation in mammals
  • is a novel factor for hemoglobin production and core fucosylation plays an important role in erythroid differentiation
  • plays potentially a dual role in TGFB1/activin-mediated signaling
  • Golgi-localized alpha1,6 fucosyltransferase that is essential for transferring the monosaccharide fucose into N-linked glycoproteins, a process known as “core fucosylation"
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1
  • cell & other
    REGULATION
    Other can be regulated also through miRNA-mediated mechanisms
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in thyroid papillary carcinoma directly linked to tumor size and lymph node metastasis
    tumoral     --over  
    in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers
    tumoral     --over  
    in nonsmall cell lung cancer (NSCLC) and correlates with tumor metastasis, disease recurrence, and poor survival
    tumoral     --other  
    altered expression of fucosylation pathway gene(FUT8), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility to pulmonary emphysema (PE)
    Variant & Polymorphism SNP
  • FUT8 gene Thr267Lys polymorphism is associated with human PE, and the Lys allele is the risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fut8-deficient (Fut8-/-) mice exhibit growth retardation, earlier postnatal death, and emphysema-like phenotype
  • Fut8-deficient mice develop pathological and physiological phenotypes resembling pulmonary emphysema (PE)