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FLASH GENE
Symbol SELE contributors: mct - updated : 03-01-2013
HGNC name selectin E (endothelial adhesion molecule 1)
HGNC id 10718
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal C-type lectin domain
  • an EGF-like motif
  • six short consensus repeats, sushi structure
  • six conserved cysteines per repeat
  • a short cytoplasmic tail
  • HOMOLOGY
    interspecies homolog to murine Sele
    Homologene
    FAMILY Selectin/Lecam family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    text type 1 membrane protein
    basic FUNCTION
  • participating in the interaction between leukocytes and the endothelium and may be involved in the pathogenesis of atherosclerosis
  • plays critical roles in tethering leukocytes to endothelial cells (ECs)
  • pivotal molecule for endothelial progenitor cells homing to ischemic limb and vasculogenesis
  • during inflammation, SELE-expressed on cytokine-activated endothelial cells mediates leukocyte rolling under flow
  • SELE clusters in both clathrin-coated pits and lipid rafts of endothelial cells but is internalized in clathrin-coated pits
  • expressed by cardiac fibroblasts with ICAM1 and CXC chemokines in response to proinflammatory cytokine stimulation in the infarcted myocardium
  • might be an important factor involved in the process of cerebral aneurysm formation and rupture, by promoting inflammation and weakening cerebral artery walls
  • role of endothelial cell adhesion molecules SELP, SELE and ICAM1 in leucocyte recruitment induced by exogenous methylglyoxal in diabetes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOXA9 acts as an obligate proinflammatory factor by mediating cytokine induction of SELE
  • CD40/CD40L interaction induces SELE-dependent adhesion of leukocytes to endothelial cells and reduces endothelial cell migration
  • MUC16 is the SELE and SELL ligand expressed by metastatic pancreatic cancer cells
  • stimulus-dependent methylation of HOXA9 is essential for SELE expression during the endothelial cells inflammatory response
  • ADRB3 stimulation acts through up-regulation of SELE in adipose tissue endothelial cells to induce neutrophil infiltration
  • cell & other
    REGULATION
    induced by IL1B,TNFA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    reduced leucocyte rolling velocity
    constitutional     --over  
    in patients with hereditary angioedema, during inter-attack periods
    Susceptibility
  • to atherosclerosis
  • to essential hypertension
  • to pancreatic cancer development
  • Variant & Polymorphism other
  • mutations of the gene may be a risk factor in atherosclerosis
  • S128R "C" allele may confer an increased susceptibility to pancreatic cancer development
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS