basic FUNCTION
| serine/threonine kinase involved in the regulation of cell motility |
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involved in TRAF2-NF-kappaB signaling pathway |
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neurofilament head/rod domain kinase that may contribute to the pathogenic process in ALS |
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plays a critical role in regulating constitutive IKK/JNK activity in unstimulated cells |
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involved in TRAF1 phosphorylation, thereby playing a critical role in the negative regulation of tonic activity of the two central inflammatory signaling pathways |
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role in ovarian cancer development or progression |
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stress-activated protein kinase, mediating phosphorylation of alpha B crystallin and stimulation of proteasome activity, which, in part, mediates the protective effect of PKN1 in the heart |
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PKN1 and PKN3 phosphorylate serine residues in sequence contexts that have an arginine residue in position -3 |
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neuroprotective role of PKN1 in hypoxia |