Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PKN1 contributors: mct - updated : 13-06-2018
HGNC name protein kinase N1
HGNC id 9405
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal leucine-zipper-like domain, and three tandem HR1 domains (the second HR1 domain plays a role in binding to RHOA), and N-terminal region of PKN1, PKN2, PKN3 plays a role in their regulation
  • a catalytic domain typical of the PRK family
  • TRAF2-binding consensus sequences PXQX (S/T) at amino acid residues 580-584 (PIQES)
  • HOMOLOGY
    interspecies homolog to murine Prkcl1
    homolog to C.elegans f46f6.2
    Homologene
    FAMILY
  • serine/threonine kinase family
  • protein kinase C superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase involved in the regulation of cell motility
  • involved in TRAF2-NF-kappaB signaling pathway
  • neurofilament head/rod domain kinase that may contribute to the pathogenic process in ALS
  • plays a critical role in regulating constitutive IKK/JNK activity in unstimulated cells
  • involved in TRAF1 phosphorylation, thereby playing a critical role in the negative regulation of tonic activity of the two central inflammatory signaling pathways
  • role in ovarian cancer development or progression
  • stress-activated protein kinase, mediating phosphorylation of alpha B crystallin and stimulation of proteasome activity, which, in part, mediates the protective effect of PKN1 in the heart
  • PKN1 and PKN3 phosphorylate serine residues in sequence contexts that have an arginine residue in position -3
  • neuroprotective role of PKN1 in hypoxia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    actication of JUN kinase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDK1 (phosphoinositide-dependent protein kinase 1)
  • interacting with TRAF2, directly binding to the TRAF domain of TRAF2
  • TRAF1 is a substrate of PKN1 kinase activity, and the phosphorylation event is required for attenuating downstream kinase activities
  • MSX1 cooperates with PKN1 to down-regulate MYF5 and, therefore, prevent the differentiation of myogenic precursor cells
  • cell & other
    REGULATION
    activated by fatty acid and Rho and limited proteolysis with trypsin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS