motifs/domains
| N-terminal tandem of PHD fingers (PHD1/2) linked by a stretch of 30 AAs, necessary for transcriptional repressive functions (PHD1 and PHD2) each contribute to the activity of CHD4, but PHD2 plays a more important role than PHD1) with tandem chromodomains in addition to centrally located ATPase/helicase domains |
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a nucleosome remodeling ATPase domain along with the two chromodomains |
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a central helicase: ATPase related SNF2 domain and a region with similarity to the Myb-DNA binding domain |
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SWI2/SNF2 ATPase/helicase domain of CHD4 is large (465 AAs) and complex, and ATPase domain with C terminus of CHD4 are necessary for the transcriptional repressive function of NuRD complexe |
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a pericentrin-binding domain |
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two domains of unknown function (DUFs) |
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C-terminal domain (CTD) |
basic FUNCTION
| involved in transcriptional repression in the nucleus, co-localize with MCRS1 in the nucleolus and appear to activate the rRNA transcription |
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required at several steps during T cell development: for differentiation of beta selected immature thymocytes, for developmental expression of CD4, and for cell divisions in mature T cells |
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novel functions for CHD4 in the DNA-damage response (DDR) and cell-cycle control |
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acts as an important regulator of the G1/S cell-cycle transition by controlling TP53 deacetylation |
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an important role of CHD4 in controlling homologous recombination repair to maintain genome stability |
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SMARCA4 and CHD4 antagonistically modulate Wnt signaling in developing yolk sac vessels to mediate normal vascular remodeling |
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ATP-dependent chromatin remodeler involved in epigenetic regulation of gene transcription, DNA repair, and cell cycle progression |
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is not only a chromatin remodeler but also a critical subunit of a multiprotein histone deacetylase complex, suggesting that alteration in chromatin modeling and histone acetylation may be the culprit |