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FLASH GENE
Symbol PRM2 contributors: mct/npt - updated : 17-07-2008
HGNC name protamine 2
HGNC id 9448
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Prm2
homolog to C.elegans B0310.4
Homologene
FAMILY
  • protamine P2 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text nucleosome
    basic FUNCTION
  • substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis
  • basic chromosomal protein that replace the histones during chromatin remodeling
  • during mammalian spermatogenesis, involved in the substantial condensation of the chromatin structure (Kempisty 2007)
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • spermatogenesis
  • mitotic chromosome condensation (DNA packaging)
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduction in contents of PRM1 and PRM2 transcripts in spermatozoa may be linked with asthenozoospermia (Kempisty 2007)
    Susceptibility to male infertility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS