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FLASH GENE
Symbol GSTM3 contributors: mct - updated : 17-07-2008
HGNC name glutathione S-transferase M3 (brain)
HGNC id 4635
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Gstm3
homolog to C.elegans T28A11.11
Homologene
FAMILY
  • GST superfamily
  • mu family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • establishment of blood/nerve barrier
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text germline maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypertension
  • to Alzheimer disease
    • Variant & Polymorphism other polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS