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FLASH GENE
Symbol FZD6 contributors: mct - updated : 25-10-2011
HGNC name frizzled homolog 6 (Drosophila)
HGNC id 4044
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich domain
  • seven transmembrane segments (7TM) without the C terminal S/T-X-X-X-W motif
  • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity gene
    Homologene
    FAMILY
  • G-protein coupled receptor Fz/Smo family
  • 'frizzled' gene family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating Dishevelled
  • involved in signal transduction
  • exhibiting characteristics of a WNT receptor
  • repressingthe canonical Wnt cascade activated also by various Wnt signaling intracellular mediators such as Dishevelled-1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • homotypic intracellular interactions of CELSR1 are required to recruit VANGL2 and FZD6 to sites of cell-cell contact (Devenport 2008)
  • DVL1 regulates precoupling of heterotrimeric G proteins to FZD6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDI
    Susceptibility to neural tube defects (NTD)
    Variant & Polymorphism SNP
  • nonsynonymous variants in FZD6 may contribute to NTD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS