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FLASH GENE
Symbol AKAP8 contributors: mct - updated : 02-01-2017
HGNC name a kinase (PRKA) anchor protein 8
HGNC id 378
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amphipathic helix binding domain
  • HOMOLOGY
    interspecies homolog to rattus Akap95
    Homologene
    FAMILY
  • AKAP95 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in the nucleus during interphase and is distinctly redistributed during mitosis
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • having a cell cycle-dependent interaction with the RII subunit of PKA
  • involved in the process of apoptotic nuclear morphological changes
  • potential carrier protein for active caspase 3 from the cytoplasm into the nuclei in apoptotic cells
  • regulation of transcription by the KMT2B complex and MLL complex-associated AKAP8
  • involvement of AKAP8 in proper spindle assembly checkpoint (SAC) function likely through its interaction with TPR
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • caspase 3-binding protein
  • partner for D-type cyclins
  • TPR is a novel AKAP8 binding partner
  • cell & other
    REGULATION
    Other maybe cell cycle dependent
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS