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FLASH GENE
Symbol NDUFS4 contributors: mct - updated : 29-09-2010
HGNC name NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
HGNC id 7711
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extrinsic domain, mitochondrial signal peptide
    • secondary structure seven subunit mitochondrial, 34 subunit nuclear, forty different subunits
    mono polymer polymer
    isoforms Precursor precursor of 18kDa
    HOMOLOGY
    interspecies homolog to murine Ndufs4
    Homologene
    FAMILY
  • complex I NDUFS4 subunit family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • NADH ubiquitine dehydrogenase (Q reductase), assembly of a functional complex 1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFS4 , CMTND1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS