basic FUNCTION
| may be having a role in calcium homeostasis |
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NUCB2/ERAP1 complexes, which associate with TNFRSF1A play an important role in mediating TNFRSF1A release to the extracellular compartment |
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NUCB1 and NUCB2 are multifunctional proteins that interact with Ca(2+), nucleic acids and various regulatory proteins in different signaling pathways |
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novel action, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity |
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NUCB2-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway |
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mediator of anorexia and catabolism in the central nervous system |
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role for NUCB2 in beta-cell function and a potential involvement in diabetic pathology |
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anorexigenic signal, acting in a leptin-independent manner |
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indispensable role of NUCB2 in the central networks driving puberty onset, a function that may contribute to its functional coupling to energy homeostasis |
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could play an important role in the protection against the development of obesity in male subjects and might have an influence on energy homeostasis |
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play an important role in metabolic control through its anorexigenic and anti-hyperglycemic effects |
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adipocytokine which exerts not only anorexigenic but also hypertensive roles through acting on hypothalamus melanocortin-3/4 receptors |
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modulates blood pressure through directly acting on peripheral arterial resistance |