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FLASH GENE
Symbol NUCB2 contributors: mct - updated : 18-05-2012
HGNC name nucleobindin 2
HGNC id 8044
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic acidic AA rich putative DNA binding domain with a potential nuclear localization signal (NLS)
  • two helix-loop-helix (HLH) motifs, that exhibit two EF-hand calcium binding motifs
  • an acidic AA rich region between the two HLH motifs and a leucine zipper motif
  • NUCB1 and NUCB2, two highly homologous calcium-binding proteins, share a common motif with CCDC88A for Galpha(i) binding and activation
  • HOMOLOGY
    interspecies homolog to murine Nucb2
    intraspecies homolog to calmodulin
    Homologene
    FAMILY nucleobindin family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be having a role in calcium homeostasis
  • NUCB2/ERAP1 complexes, which associate with TNFRSF1A play an important role in mediating TNFRSF1A release to the extracellular compartment
  • NUCB1 and NUCB2 are multifunctional proteins that interact with Ca(2+), nucleic acids and various regulatory proteins in different signaling pathways
  • novel action, in addition to its anorexigenic effects, to stimulate autonomic nervous system activity
  • NUCB2-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
  • mediator of anorexia and catabolism in the central nervous system
  • role for NUCB2 in beta-cell function and a potential involvement in diabetic pathology
  • anorexigenic signal, acting in a leptin-independent manner
  • indispensable role of NUCB2 in the central networks driving puberty onset, a function that may contribute to its functional coupling to energy homeostasis
  • could play an important role in the protection against the development of obesity in male subjects and might have an influence on energy homeostasis
  • play an important role in metabolic control through its anorexigenic and anti-hyperglycemic effects
  • adipocytokine which exerts not only anorexigenic but also hypertensive roles through acting on hypothalamus melanocortin-3/4 receptors
  • modulates blood pressure through directly acting on peripheral arterial resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    a component NUCB2/ERAP1 complexes
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with necdin (necdin with NUCB2 might be involved in Ca(2+) homeostasis in neuronal cytoplasm)
  • its functions could be modulated by caspase-mediated cleavage in apoptosis
  • role of SMIM20 in stress response and possible interactions with NUCB2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by estrogens and plays an important role, especially in the process of metastasis, in breast carcinomas
    Susceptibility to obesity in men
    Variant & Polymorphism SNP
  • rs1330, rs214101 and rs757081 are associated with obesity in men
  • Candidate gene
    Marker potent prognostic factor in breast cancer
    Therapy target
    ANIMAL & CELL MODELS