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FLASH GENE
Symbol KIF3C contributors: mct - updated : 28-09-2017
HGNC name kinesin family member 3C
HGNC id 6321
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal globular domain, the motor domain with an ATP and the microtubule binding sites
  • a long alpa-helical coiled-coil region (stalk region), involved in dimerization
  • a small C terminal domain, potentially involved in interaction with other proteins, vesicles or organelles
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Kif3c
    homolog to Drosophila Klp68D
    homolog to C.elegans klp-11
    Homologene
    FAMILY
  • kinesin-like protein family of microtubule-associated motor proteins
  • kinesin II subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • acting as microtubule-based anterograde translocator for membranous organelles
  • playing a role in various intracellular transport and spindle formation
  • KIF3B mutant photoreceptor cilia differentiate with a delay, suggesting that KIF3C, although redundant with KIF3B at later stages of differentiation, is not active early in photoreceptor ciliogenesis
  • is a key regulator of axonal growth and regeneration by controlling microtubule dynamics and organization in the growth cone
  • KIF3C is an injury-specific kinesin that contributes to axon growth and regeneration by regulating and organizing the microtubule cytoskeleton in the growth cone
  • functions as a motor protein involved in axonal transport in neuronal cells
  • KIF3A, KIF3B, KIF3C is classified as a heterotrimeric kinesin-2 that is best known for organelle transport in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text non-selective vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of KIF3A and KIF3C
  • intermolecular communication within the KIF3AC heterodimer modulates entry into the processive run regardless of whether the run is initiated by the KIF3A or KIF3C motor domain
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • FMR1-interacting protein (FMR1 is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of KIF3C in breast cancer may be associated with the tumor progression and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS