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FLASH GENE
Symbol B4GALT2 contributors: mct/npt - updated : 01-12-2015
HGNC name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
HGNC id 925
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophobic signal sequence
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • beta-4- galactosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • trans Golgi
  • type II transmembrane glycoprotein
  • basic FUNCTION
  • synthesis of N acetylactosamine in glycolipids and glycoproteins
  • one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans and its expression is significantly altered during oncogenesis
  • play important roles in the extension of N- and O-linked glycans involved in several biological events
  • major regulator of the synthesis of glycans involved in neuronal development
  • specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha lactalbumin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS