basic FUNCTION
| ubiquitin-specific protease, stimulating viral gene expression |
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playing a role in the pathogenesis of spinocerebellar ataxia type 1 |
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deubiquitylating enzyme playing a role not only in transcriptional regulation but also in DNA replication, apoptosis, and possibly endosomal organization |
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has an important role in regulating FOXO-mediated stress responses |
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can stabilize MARCH7, and deubiquitylate MARCH7 in the nucleus |
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deubiquitinase that critically regulates the TP53-MDM2 pathway and modulates the TP53 function, inducing TP53-dependent cell growth repression and apoptosis |
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USP7 is a deubiquitinating enzyme that regulates the ubiquitination state of RNF2 |
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stabilizes REST through deubiquitylation and antagonizes beta-TrCP in regulating REST at the post-translational level |
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counterbalances REST ubiquitylation and prevents neural stem/progenitor cells (NPCs) differentiation, and USP7-mediated deubiquitylation represents a critical regulatory mechanism involved in the maintenance of NPCs |
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involved in the cellular stress response by regulating MDM2 and TP53 protein levels following severe DNA damage |
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stimulates repair of oxidative DNA lesions |
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has a critical role in regulating the TP53-MDM2 (murine double minute 2) pathway |
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USP7-mediated TP53 regulation is crucial for brain development |
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dual role of USP7, regulating the protein turnover of UHRF1 and stimulating the enzymatic activity of DNMT1 |
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regulates the stability of TP53 and the TP53-binding protein MDM2 |
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plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response |
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its regulation plays a central role in DNA damage signal transmission |
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UVSSA, together with USP7, is implicated in regulating |
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Transcription-coupled nucleotide excision repair (TC-NER) activity |
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NMRAL1 and USP7 function in concert in inhibiting polyubiquination of IKBKG, thus inhibiting NFKB activity |
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is a protein deubiquitinase with an essential role in development |
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USP7 may act as an oncogenic protein that can modulate MYC expression via TRRAP |
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is a novel component of the cellular DDR involved in preserving the genome stability |
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TRIM32 associates with the deubiquitination enzyme USP7, which previously has been implicated in neural stem cell maintenance, and exhibit a dynamic and partially overlapping expression pattern during neuronal differentiation |
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