Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DNAJC7 contributors: mct - updated : 22-08-2014
HGNC name DnaJ (Hsp40) homolog, subfamily C, member 7
HGNC id 12392
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine tetratricopeptide repeats
  • a region of similarity with the DnaJ protein family
  • and a coiled coil domain within the TPR domain
  • two N-terminal tetratricopeptide repeat domains
  • a C-terminal DNAJ domain
  • HOMOLOGY
    interspecies homolog to murine Dnajc7
    homolog to Drosophila Tpr2
    intraspecies homolog to PRKP1
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • implicated in steroid receptor chaperoning
  • participates in TP53/MDM2 negative feedback regulatory pathway, and thereby enhancing the stability and activity of TP53
  • has an ability to enhance TP53-dependent transcriptional activation
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS development
    text preventing protein aggregation
    PATHWAY
    metabolism
    signaling
    a component
  • DNAJC7 directly interacts with the ligand-binding domain of NR1I3 and mediates the formation of a cytoplasmic NR1I3-DNAJC7-HSP90 ternary complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GAP-related domain of NF1,via its TPR region
  • DNAJC7 is associated with TP53 in mammalian cells
  • ubiquitin-proteasomal regulation of DNAJC7 and HSPA4 are important contributors to the regulation of cytoplasmic NR1I3 levels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS