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FLASH GENE
Symbol DTNB contributors: mct/npt - updated : 20-05-2016
HGNC name dystrobrevin, beta
HGNC id 3058
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a zinc finger ZZ type
  • HOMOLOGY
    intraspecies paralog to DTNA,significantly
    homolog to dystrophin
    Homologene
    FAMILY
  • dystrophin associated complex family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the formation and stability of synapses
  • may play an important role in intracellular signal transduction, in addition to providing a membrane scaffold in muscle
  • having a function as a motor protein receptor that might play a major role in the transport of components of the dystrophin-associated protein complex to specific sites in the cell
  • role for dystrobrevin as a scaffold protein that may play a role in different cellular processes involving PRKAR1A signaling
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
  • copurifying with DP71 and DP140 dystrophins
  • component of the dystrophin glycoprotein complex with dystrophin, syntrophins DNTB1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind directly to dystrophin and are components of a transmembrane dystrophin-glycoprotein complex (DGC) that links the cytoskeleton to extracellular proteins in many tissues
  • binds to RE-1 and represses the promoter activity of synapsin I, a REST-responsive gene that is a marker for neuronal differentiation
  • direct interaction witht HMG20A and HMG20B, suggesting that DTNB may be involved in regulating chromatin dynamics, possibly playing a role in neuronal differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • synaptic and behavioral abnormalities are minimal in mice lacking either Dtna or Dtnb