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FLASH GENE
Symbol CAPN5 contributors: mct - updated : 11-07-2017
HGNC name calpain 5
HGNC id 1482
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal regulatory domain processed after activation, and an N-terminal monopartite NLS
  • protein domain (II), linker (III)
  • C terminal T domain (not containing a calmodulin-like EF hand motifs), and a unique bipartite NLS closer to the C terminus; C-terminal NLS contains a SUMO-interacting motif that contributes to nuclear localization, and mutation or deletion of both NLS renders CAPN5 exclusively cytosolic
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans sex determination gene tra3
    Homologene
    FAMILY
  • papain superfamily, nCL-3 type
  • olfactory marker protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • calcium dependent neutral cysteine proteinase (non lysosomal)
  • may act as a modulator of the olfactory signal- transduction cascade
  • calcium-activated cysteine protease
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text signal transduction
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterodimerezing with a small subunit
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • interacts with BEX1 and BEX2
  • CAPN5 is a target of HOXA10 transcriptional regulation in endometrial cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in both stromal and glandular cells from women with endometriosis compared with that of fertile controls
    Susceptibility to polycystic ovary syndrome
    Variant & Polymorphism other GGCA and GGTG were overrepresented in polycystic ovary syndrome patients
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS