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FLASH GENE
Symbol CS contributors: mct - updated : 07-06-2018
HGNC name citrate synthase
HGNC id 2422
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
isoforms Precursor
HOMOLOGY
Homologene
FAMILY
  • citrate synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    tricarboxylic acid cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CS is a direct RORA target gene and one mechanism by which RORA regulates lipid metabolism is via regulation of CS expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    In pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS