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FLASH GENE
Symbol RERE contributors: mct - updated : 25-05-2016
HGNC name arginine-glutamic acid dipeptide (RE) repeats
HGNC id 9965
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region of alternating glutamine and proline residues
  • a region of arginine aspartic
  • ELM2 (EGL-27 and MTA1 homology 2) domain, and SANT (SWI3/ADA2/N-CoR/TFIII-B) domain, which are also present in other important transcriptional cofactors (both domains orchestrate molecular events that lead to a stable methylation of histone H3-lysine 9)
  • HOMOLOGY
    interspecies homolog to rattus Atn1 protein
    intraspecies homolog to DRPLA,C terminal portion of RERE
    Homologene
    FAMILY Atrophin family proteins
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • FAT1 and RERE colocalized at cell-cell junctions, in the perinuclear area, and in the nucleus
  • basic FUNCTION
  • protein protein interaction
  • ATN1 and RERE function as bifunctional transcriptional regulators
  • required for the normal patterning of the early vertebrate embryo, including the central nervous system, pharyngeal arches, and limbs
  • playing an important role in the control of cell survival
  • FAT1 and ATRS (ATN1 and RERE), act in concert after vascular injury but show further that distinct Atr isoforms have disparate effects on vascular smooth muscle cells directional migration
  • controls retinoic acid signalling, which is required to maintain somite symmetry by interacting with FGF8 in the left-right signalling pathway
  • controls retinoic acid signalling and somite bilateral symmetry
  • nuclear receptor coregulator that positively regulates retinoic acid signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component RERE forms a complex with NR2F2, EP300 and a retinoic acid receptor, which is recruited to the retinoic acid regulatory element of retinoic acid targets
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding DRPLA enhancer by extended polyglutamine
  • binds histone deacetylase 1 and 2 (HDAC1/2), and orphan nuclear receptors such as NR2E1
  • interactions between FAT1 and Atrophins (ATN1, RERE) might contribute to FAT1 effects on vascular smooth muscle cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RERED
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mutation in Rere leads to the formation of asymmetrical somites in mouse embryos, similar to embryos deprived of retinoic acid