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FLASH GENE
Symbol PLCH2 contributors: - updated : 22-11-2006
HGNC name phospholipase C, eta 2
HGNC id 29037
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2 domain
  • an EF-hand domain
  • a PI-PLC X-box domain
  • a PI-PLC Y-box domain
  • HOMOLOGY
    intraspecies homolog to chain precursor of collagen IV alpha 4
    Homologene
    FAMILY
  • phosphoinositide-specific phospholipase C (PLC) superfamily
  • the PLC-eta family
  • CATEGORY enzyme , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • likely involved in signal transduction pathways (Stewart 2005)
  • phosphoinositide phospholipase C activity activated by G protein beta-1-gamma-2 dimers (Zhou 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS