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FLASH GENE
Symbol SGSM2 contributors: mct - updated : 29-09-2014
HGNC name small G protein signaling modulator 2
HGNC id 29026
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RUN and TBC motifs
  • RAPID motifs
  • HOMOLOGY
    interspecies homolog to C.elegans cosmid C38H2
    Homologene
    FAMILY SGSM family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • modulator of the small G protein RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways
  • influenced the ability of RAB32 to bind its effector protein, ANKRD27, consistent with a physiological role for SGSM2 in regulating RAB32
  • multidomain protein binding RAB9A in a nucleotide-dependent manner but serves as a GAP for at least one other Rab GTPase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with RAP family proteins via novel RAP interacting domain (RAPID) motif
  • interact with several members of RAB family
  • RAB9A binding did not influence GAP activity of bead-bound SGSM2 protein
  • potential involvement of RAB9A in the regulation of the SGSM2 localization and in the trafficking of melanogenic enzymes (RAB32, RAB38, TYRP1)
  • functions as a GTPase-activating protein for RAB32/38 and regulates melanogenic enzyme trafficking in melanocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS