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FLASH GENE
Symbol ZHX3 contributors: mct/npt - updated : 26-05-2020
HGNC name zinc fingers and homeoboxes 3
HGNC id 15935
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two C2H2-type zinc fingers
  • five homeodomains (HDs) as well as ZHX1
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Zhx3 (84 pc)
    intraspecies paralog to ZHX1
    paralog to ZHX2
    Homologene
    FAMILY
  • zinc fingers and homeoboxes (ZHX) gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text mostly sequestered in the non-nuclear compartment in the normal podocyte by virtue of heterodimer formation, and loss of heterodimerization was associated with entry into the nucleus
    basic FUNCTION
  • major transcriptional mediator of podocyte disease
  • having a transcriptional repressor activity
  • ZHX2 and ZHX3 were involved in the transcriptional repression of the hepatocellular cacinoma markers in normal hepatocytes, suggesting that the failure of the ZHX2 and/or ZHX3 expression might be a critical factor in the hepatocellular carcinogenesis
  • ZHX1, ZHX2, ZHX3 have biological roles in cell cycle control by acting as co-repressors of the transcriptional regulator Nuclear Factor Y
  • is involved in the switch from the undifferentiated state of mesenchymal stem cells (MSC) to an osteogenic program
  • podocyte ZHX2 imbalance is a critical factor in glomerular disease, with minimal change disease disparities mediated mostly through ZHX1, and focal segmental glomerulosclerosis deviations through ZHX3 and ZHX2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizes with both ZHX1 and ZHX2
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with the activation domain of the NF-YA
  • able to form a heterodimer with ZHX2 via a region containing each HD1(homeodomain)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in nephrotic syndrome prior to the onset of proteinuria, and recovery of expression was associated with migration of ZHX3 protein into the nucleus and the development of proteinuria
    tumoral     --low  
    in clear cell Renal cell carcinoma (RCC), significantly associated with pathological stage
    tumoral     --over  
    high mRNA levels of ZHX2 and ZHX3 correlated with better overall survival in patients with breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be useful as an early osteogenic differentiation marker
  • ZHX3 expression may serve as an independent high-risk prognostic predictor
  • Therapy target
    ANIMAL & CELL MODELS