basic FUNCTION
| acting as a negative regulator of the NOTCH pathway, key regulator of the cellular proliferation and specication process |
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playing an important role in the growth and aggressiveness of pancreatic carcinoma and having an impact on the expression of genes involved in regulation of cellular growth, possibly through the TGF-beta signaling pathway |
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. may be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins |
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playing a crucial role for dislocation of Class I major histocompatibility complex heavy chains by the human cytomegalovirus US11 protein |
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nucleates a protein complex required for dislocation of misfolded glycoproteins |
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regulation of the stability and assembly of the SYVN1-SEL1L complex is critical to optimize the degradation kinetics of ERAD substrates |
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stabilization and assembly of the SYVN1-SEL1L complex thus play a central role in mammalian ERAD regulation |
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potentially required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins |