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FLASH GENE
Symbol CSNK1G2 contributors: npt - updated : 14-06-2002
HGNC name casein kinase 1, gamma 2
HGNC id 2455
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a channel proline-rich sequence
  • a SH3 domain
  • a characteristic CKSG signature at C terminus
  • conjugated PhosphoP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CK1 Ser/Thr protein kinase family
  • casein kinase I subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • casein kinase 1, may be involved in signaling pathways downstream of RTKS
  • phosphorylates and modulates the functions of MTA1, and that these extranuclear effects of estrogen might have important implications in regulating the functions of MTA1 in mammary epithelial and cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with the SH3 domain of the adapter proteins NCK1 or NCK2
  • preferentially acidic proteins, broad specificity
  • bind to PER1 and to promote its degradation
  • MTA1-binding protein
  • cell & other
    REGULATION
    induced by estrogen that stimulates its activity , effectively blocked by a specific inhibitor of CKI
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS