protein
| PEX9, PEX26 |
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interacts with PEX6 (each contain two AAA domains and hetero-oligomerize)(Zhang 2010) |
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peroxisomal C-tail-anchored type-II membrane protein, PEX26, recruits AAA ATPase PEX1-PEX6 complexes to peroxisomes |
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PEX1 and PEX6 are most likely regulated in their peroxisomal localization onto PEX26 via conformational changes by the ATPase cycle |
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N-terminal region in PEX26 acts as a scaffold protein to recruit PEX14·PEX5 complex together with PEX1·PEX6 complexes on peroxisomes |
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PEX1, PEX6, PEX26 are responsible for the downregulation of pexophagy, the autophagic degradation of peroxisomes |
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PEX1-PEX6 complexes facilitate the export of the peroxisomal matrix protein receptor PEX5 back into the cytosol after PEX5 has delivered its cargo to the peroxisome |