SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus
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| intracellular,nuclear envelope
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| text
| expressed in the growth plate in infancy and the level of expression declines during pubertal progression (localized to the resting and hypertrophic zones, being absent from the proliferative zone) |
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localized both intracellularly and in the plasma membrane and subject to limited basal endocytosis  |
| basic FUNCTION
| intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology |
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mediates the nongenomic signaling of 17beta-estradiol (E2) in a variety of estrogen-sensitive cancer cells through activation of the epidermal growth factor receptor (EGFR) pathway |
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playing a potential role as a modulator of pubertal growth, and could be involved in the modulation of longitudinal bone growth during puberty |
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playing an important role for the inhibitory effect of progestin on cellular growth |
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G protein-coupled receptor for estrogen that responds to estrogen with rapid cellular signaling |
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indispensable for thymocyte apoptosis that preferentially occurs in T cell receptor beta chain(-/low) double-positive thymocytes |
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responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production |
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GPR30-mediated inhibition of urothelial cell proliferation is the result of decreased CCND1 by down-regulation of activation protein-1 signaling |
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mediate some of the rapid signal transduction events following cell stimulation, such as calcium mobilization and kinase activation, and it also appears to regulate rapid transcriptional activation of genes such as c-fos |
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antagonizes growth of ESR1-positive breast cancer |
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implicated in rapid non-genomic effects of estrogens |
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may have potential functions during sperm migration at midcycle as well as decidualization and blastocyst implantation in the mid-secretory phase |
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role in estrogen protection against ischaemic stress |
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activation of GPER1 enhances cholinergic function in the hippocampus similar to E2 |
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ESR1, ESR2 and GPER1 are involved in preventing beta-cell apoptosis, impeding the loss of critical beta-cell mass |
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endogenous GPER1 inhibits EDN1-induced vasoconstriction, an effect that may be associated with reduced VSMC Ca(2+) sensitivity) |
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regulates endothelin-dependent vascular tone and intracellular calcium |
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normal endometrial GPER1 expression is cyclic and regulated by nuclear estrogen and progesterone receptors, while expression is dysregulated in endometriosis |
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IGF1 system regulates GPER1 expression and function, triggering the activation of a signaling network that leads to the migration and proliferation of cancer cells |
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endothelial GPER1 is a novel regulator of the inflammatory response which could be a potential therapeutic target against atherosclerosis and other inflammatory diseases |
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important role in mediating the rapid signaling and neuroprotective actions of E2 in the hippocampus |
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is crucial in modulating glomerular mesangial cell function including extracellular matrix production and migration |
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GPER1 forms a plasma membrane complex with a membrane-associated guanylate kinase and AKAP5 |
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may be included among the complex network of transduction signaling triggered by insulin that drives cells toward cancer progression |
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is the estrogen receptor that mediates the anorectic effect of estrogen through the STAT3 pathway in the hypothalamus |
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plays an important role in mediating the effects of estradiol |
