basic FUNCTION
| regulator of the sarco(endo)plasmic reticulum Ca(2+)-ATPase of fast-twitch skeletal muscle (SERCA1a) |
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inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) |
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its downregulation could play an important role in abnormal intracellular Ca2+ cycling in atrial pathology |
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is likely an important mediator of muscle thermogenesis and whole-body energy metabolism |
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effect of PLN and SLN, which becomes synergic when they are both present in the SR membrane, is expected to favor a rapid equilibration of ions on both sides of the membrane |
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SLN provides likely a novel mechanism of adaptive thermogenesis within skeletal muscle and protects against diet-induced obesity |
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important role for SLN in muscle metabolism and energy expenditure |
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SLN and its close analog phospholamban (PLN) are membrane proteins that regulate SERCA by inhibiting Ca(2+) transport in skeletal and cardiac muscl |
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small proteolipid and a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPase |
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transmembrane protein that can form a self-assembled pentamer |
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SLN, not PLN, is required for muscle-based thermogenesis |
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regulator of ATP2A1 activity in muscle, playing an important role in regulating muscle thermogenesis and metabolism |
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potential role for SLN during increased metabolic demand |
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plays an important role in adaptive muscle remodeling potentially through calcineurin stimulation, which could have important implications for other muscle diseases and conditions |
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plays crucial roles in heat production through modifying the function of sarco/endoplasmic reticulum Ca2+ ATPase, thereby being involved in thermogenesis and systemic metabolism |