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FLASH GENE
Symbol PPL contributors: mct - updated : 25-05-2012
HGNC name periplakin
HGNC id 9273
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a globular N terminus, interacting with plectin to regulate keratin organisation and epithelial migration (
  • a central alpha helical coiled coil (rod) domain
  • a C-terminal tail consisting of characteristic repeat sequences
  • that may stabilise the interaction of the EVPL C-terminus with intermediate filaments
    HOMOLOGY
    interspecies homolog to murine Ppl
    Homologene
    FAMILY plakin family of cell junction proteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • may be linking the cornified envelope to desmosomes and intermediate filaments
  • can function in relocating protein kinase B into various cell compartments
  • component of desmosomes and the epidermal cornified envelope
  • first protein described to modify the capacity of the melanin-concentrating hormone-1 receptor to initiate signal transduction
  • cytoskeletal linker protein that participates in the assembly of epidermal cell cornified envelope and regulates keratin organisation in simple epithelial cells
  • with Involucrin, and EVPL, form the protein scaffold on which the cornified envelope assembles
  • arterial intima-enriched (AIE) gene, with periplakin, SPRR3, envoplakin, galectin 7, and plakoglobin that are functionally related in that they contribute to the stress properties of stratified epithelium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerises with EVPL via its rod domain
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PKB
  • ANXA9 is a novel interacting partner for periplakin (PPL)N-terminus
  • cell & other
    REGULATION
    Other regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS