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Symbol MAPK7 contributors: mct - updated : 31-08-2018
HGNC name mitogen-activated protein kinase 7
HGNC id 6880
  • conserved thr-glu-tyr activation motif
  • a unique long C-tail, suggesting specific mechanisms of regulation
  • canonical TXY motif within the activation loop of the classical MAPKs is replaced by SEG
  • a novel MAPKAPK5 interaction motif (FRIEDE) within MAPK7, and MAPK4 essential for binding to the C-terminal region of MAPKAPK5, located within the L16 extension lying C-terminal to the CD (common docking) domain
    interspecies ortholog to murine Mapk7
    homolog to C.elegans f39h11.3
    intraspecies paralog to MAPK4
  • protein kinase superfamily
  • MAP kinase subfamily
  • CMGC Ser/Thr protein kinase family
  • CATEGORY enzyme , transcription factor , signaling , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
  • translocates to the nucleus upon prolactin stimulation
  • basic FUNCTION
  • serine-threonine kinase, involved in the transcriptional activation of factors modulating expression of genes required for cell proliferation
  • promotes the growth of hepatocellular carcinomas cells by regulating mitotic entry
  • playing a role during brain development and raise the interesting possibility that extrinsic factors may instruct cortical progenitors to become neurons by activating the ERK5 pathway
  • may be promting neuronal fate specification and contributing to cortical development
  • negative regulator of HIF1A and angiogenesis by increasing HIF1A ubiquitination and inhibiting HIF1A activity in endothelial cells
  • having a critical role for the regulation of FOS
  • activated during the G2/M phases and may be involved in G2/M progression
  • playing a role in integrin-mediated cell adhesion and motility in cancer cells via PTK2 signaling
  • potential importance in aggressive prostate cancer
  • required for AKT phosphorylation and cell survival and is crucial for endothelial cell differentiation in response to VEGFA
  • MAPK4 and MAPK7 have acquired specialized functions through evolutionary diversification
  • regulates muscle cell fusion through KLF transcription factors
  • MAPK7 and MAP2K4 could play an important role in osteosarcoma tumorigenesis
  • novel signaling pathway regulating developmental olfactory bulb neurogenesis and olfactory behavior
  • MAPK7 signaling is potentially a critical regulator of adult hippocampal neurogenesis
  • MAPK7 activation exerts NFE2L2 transcriptional activation and nuclear translocation via potential protein-protein interaction in a kinase activity-dependent manner
  • is an important mediator in prolactin-stimulated adult neurogenesis
  • essential role in prolactin-induced adult neurogenesis in the subventricular zone (SVZ)and olfactory bulb (OB)
  • is required in prolactin-induced olfactory bulb neurogenesis
  • MAPK7/MAP2K5 pathway mediates fluid shear stress induced RUNX2 expression in osteoblast differentiation
  • integration of MAPK7 with NFATC4 nucleo-cytoplasmic shuttling and PKA activation in adipocyte signaling
  • is a mediator of cancer-associated inflammation in the setting of epidermal carcinogenesis
  • proinflammatory role for MAPK7 in primary human endothelial cells and monocytes
  • multiple critical functions for MAPK7 in controlling embryonic stem cells (ESCs) identity
  • plays an essential role in the gestational augmentation of pancreatic beta-cell proliferation
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    signaling signal transduction
  • activation of MAP2K5/MAPK7 signaling strongly inhibits endothelial cells migration and results in massive morphological changes
  • novel PAK-MAPK4/MAPK7-MAPKAPK5 signaling pathway
  • PTK6-BCAR1-MAPK7 signaling cascade plays an important role in cancer cell migration and invasion
  • YAP1 promotes myogenic differentiation via the MAP2K5-MAPK7 pathway
  • a component
  • MAPK7 pathway mediates DLGs cell cycle dependent phosphorylation, which likely to have important implications in the correct timely mitotic entry and mitosis progression
    small molecule
  • MEK5, actin
  • binding YWHAB(demonstrate an inhibitory function and regulatory mechanism for BMK1)
  • critical target of PTK2 in cell adhesion signaling
  • PRKCZ binds and phosphorylates MAPK7, thereby decreasing NOS3 protein stability and contributing to early events of atherosclerosis
  • MAP5K5 activates MAPK7 and induces KLF4 to modulate TNF responses in dermal microvascular endothelial cells
  • CCL19 stimulation of na
  • ve T cells regulates expression of MAPK7, KLF2, and S1PR1
  • is a newly identified mediator of TLR2 signaling, and TLR2 signaling pathways differ in ECs and monocytes
  • MAPK7 interacts with NFE2L2 to induce its nuclear translocation and transcriptional activity
  • activation of the MAPK7/MAP2K5 pathway with CSF1R is required for osteoclast differentiation, which may induce differentiation through the induction of FOS
  • TNFSF13B activation of the MAPK7 MAP kinase pathway regulates B cell survival
  • MAPK7 mediates proinflammatory responses in primary human cells in response to stimulation of TLR2
  • ANKRD1 is a MAPK7-dependent and ERK1/2-independent gene
  • specific interactions between YAP1 and proteins in the ERK5 pathway, such as MEK kinase 3 (MAP3K3) and MAPK7
  • MAPK7 regulation of PPARGC1A is critical for cardiac mitochondrial function
  • cell & other
    activated by tyrosine and threonine phosphorylation
    Phosphorylated by PAK1, PAK2, PAK3 on Ser-186
    Other activity regulated by insulin and angiotensin II
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith-Magenis syndrome
    tumoral   amplification    
    in hepatocellular carcinoma
    tumoral     --over  
    might contribute to ovarian cancer metastasis through up-regulating type II collagen expression ( might contribute to ovarian cancer metastasis through up-regulating type II collagen expression
    Variant & Polymorphism other
    Candidate gene
  • MAPK7 and MAP2K4 could be good markers in assessing response to treatment and development of osteosarcoma
  • may be a new prognostic marker in clear cell renal cell carcinoma owing to its relationship with metastasis and more advanced stages
  • Therapy target
    may be a new therapeutic target in invasive osteosarcoma expressing MMP9
    diabetetype 1 
    may be a promising target for increasing beta-cell mass in diabetes patients
    maintenance of cardiac MAPK7 is a therapeutic approach for cardiomyopathy prevention and/or treatment
    may be a potential therapeutic target in the clinical treatment for ovarian cancer
    is a potential therapeutic target in diverse disorders that cause inflammatory critical illness
    Molecules that upregulate ERK5 and its signaling in macrophages may be good drug targets for suppressing cardiovascular diseases
  • Erk4-deficient mice are viable and fertile and exhibit no gross morphological or physiological anomalies
  • conditional deletion of the erk5 gene in mouse neural stem cells during development reduces the number of GABAergic interneurons in the main olfactory bulb (OB)