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FLASH GENE
Symbol KIR2DL3 contributors: npt/ - updated : 24-03-2007
HGNC name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
HGNC id 6331
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an extracellular region containing two C2-type Ig-like domains
  • a 19-amino acid hydrophobic transmembrane region
  • a long cytoplasmic tail with 2 ITIMs (immunoreceptor tyrosine-based inhibitory motifs)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • functioning as a receptor for class I molecules on NK cells
  • inhibiting the activity of NK cells thus preventing cell lysis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS