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FLASH GENE
Symbol LILRB1 contributors: mct/pgu - updated : 26-09-2013
HGNC name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
HGNC id 6605
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Ig extracellular domains
  • a long cytoplasmic tail
  • four tyrosine based inhibitory motifs (ITIM), tyrosine based inhibitory motifs (ITIM), cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, that down-regulate signaling by nonreceptor tyrosine kinase cascades
  • 23 AA signal peptide
  • secondary structure
  • two Iglike domains arranged at an acute angle to form a bent structure, resembling the structures of natural killer inhibitory receptor
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • leukocyte immunoglobulin-like receptor, family (LILR family)
  • related to the Fc alpha receptor and natural killed inhibitory receptor superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • maybe playing a role in T cell activation in peripheral blood
  • negatively regulate osteoclast development
  • inhibitory receptor that binds a broad range of class I HLA molecules and is encoded by the LILRB1 gene within the leukocyte receptor complex
  • its transcription is correlated with surface protein expression on NK cells
  • important mediator of immune activation and tolerance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MHC class I molecule A2
  • JUND is associated with the LILRB1 distal promoter, and depletion of JUND led to a decrease in distal promoter transcript, indicating an activating role for JUNDD in regulation of LILRB1 transcription
  • cell & other
    REGULATION
    Other developmentally regulated in mast cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS