SUBCELLULAR LOCALIZATION
| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton
|
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| intracellular,nucleus,nucleoplasm
|
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nucleus,nucleolus
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| text
| myofibrils, neuromuscular junctions |
| basic FUNCTION
| potentially involved in chaperone activity |
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involved in maintenance of cytoskeletal network in muscle (potential role in pathogenesis of myotonic dystrophy) |
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acting as an enzyme activator |
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protects hippocampal progenitor cells from glucocorticoid-induced apoptotic cell death |
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role in regulating AKT1 activation and cellular apoptosis by mediating interaction between AKT1 and its upstream activator MAPKAPK2  |
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may be involved in the pathogenesis of myotonic dystrophy and contribute to the neuropathology in both Alzheimer disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type |
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ADP-induced phosphorylation of HSP27 via MAPK3 and/or MAPK14 is sufficient for platelet granule secretion but not for platelet aggregation |
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chaperone of the myotonic dystrophy protein kinase, having a function as a novel inhibitor of apical caspase activation in the extrinsic apoptotic pathway |
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inhibits the extrinsic apoptotic pathway by suppressing apical caspases-8 and 10 activation, thereby blocking downstream apoptotic events, such as BID cleavage and caspase-3 activation |
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anti-apoptotic protein that negatively regulates apical caspase activation in the extrinsic apoptotic pathway |
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may be playing a new role in the antiapoptotic action triggered by 17beta-estradiol by modulating CASP3 activity and stabilizing EESR2 in skeletal muscle cells |
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facilitates the palmitoylation and plasma membrane translocation of the three classes of sex steroid receptors |
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multifunctional protein that participates in ubiquitination of proteins for their degradation by proteasomes |
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modulates HNRNPD proteolysis and AU-rich element-mediated mRNA degradation |
