Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PSME2 contributors: mct - updated : 02-05-2017
HGNC name proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
HGNC id 9569
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Psme2b
homolog to murine Psme2
homolog to rattus Psme2
intraspecies homolog to Ki antigen
Homologene
FAMILY
  • PSM,proteasome
  • PA28 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • proteasome activator
  • implicated in immunoproteasome assembly and required for efficient antigen processing
  • the PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasmoe
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of PSME1 and PSME2 forming a hexadimeric ring
  • ATP-dependent association of PA28 and porteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSME1
  • NAA10 suppresses 28S proteasome activity through interaction with PSME2
  • cell & other
    REGULATION
    Other stimulated by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pa28 knockout mice