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FLASH GENE
Symbol PSME1 contributors: mct/npt - updated : 10-07-2008
HGNC name proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
HGNC id 9568
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • the KEKE motif promoting binding of protein with this structural feature
  • mono polymer homomer , heteromer , dimer , heptamer
    HOMOLOGY
    interspecies homolog to murine Psme1
    homolog to rattus Psme1
    intraspecies homolog to Ki antigen
    Homologene
    FAMILY
  • PSM, proteasome
  • PA28 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • implicated in immunoproteasome assembly and required for efficient antigen processing
  • plays an important role in the generation of MHC ligands by proteasomes
  • the PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
  • involved in the presentation of endogenous antigens by MHC class I molecules
  • its function is particularly relevant for the generation of normally poorly excised peptide products
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • component 260 S proteasome hexameric activator
  • heterodimer of PSME1 and PSME2 forming a hexadimeric ring
  • able to form homoheptamers
  • ATP dependent association of PA28 and proteasome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSME1
  • PSME2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pa28 knockout mice