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FLASH GENE
Symbol THBS3 contributors: mct - updated : 21-08-2013
HGNC name thrombospondin 3
HGNC id 11787
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • four type II (EGF-like)
  • seven type III (Ca++ binding) repeats
  • a TSP C-terminal (TSPC) domain
  • a TSP N-terminal (TSPN) domain
  • conjugated GlycoP
    mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Thbs3
    Homologene
    FAMILY thrombospondin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a unique role in cell matrix interactions
  • adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions
  • highly conserved matricellular protein regulating inflammation, angiogenesis and extracellular matrix remodeling
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component oligomer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule
    protein bind to fibrinogen, fibronectin, laminin and type V collagen
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS