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FLASH GENE
Symbol SLC28A1 contributors: mct - updated : 15-04-2020
HGNC name solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
HGNC id 11001
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Slc28a2
intraspecies homolog to SLC28A2
Homologene
FAMILY
  • SLC28A family of transporter
  • concentrative nucleoside transporter (CNT) (TC 2.A.41) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • renal reabsorption transporter of physiological nucleosides, pyrimidines, adenosin and drugs
  • concentrative nucleoside transporter, sodium dependent
  • mediating the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs
  • SLC28A1, SLC28A2 are pyrimidine and purine nucleoside-selective, respectively
  • mediates the uptake of naturally occurring pyrimidine nucleosides, but also nucleoside analogs used in anticancer and antiviral therapy
  • fits the profile of a transceptor in a substrate translocation-independent manner and is likely to be relevant to tumor biology
  • is implicated in sensitizing solid tumors to nucleoside analogs
  • is a putative determinant for nucleoside analog chemoresistance in ovarian cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) URCTU
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer cell (Hubeek 2008)
    tumoral     --low  
    in tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • as a potential candidate to render drug-resistant pancreatic cancer cells amenable to chemotherapy
  • Marker
    Therapy target
    ANIMAL & CELL MODELS