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FLASH GENE
Symbol NDUFB8 contributors: mct - updated : 11-04-2018
HGNC name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
HGNC id 7703
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY complex I NDUFB8 subunit family
CATEGORY enzyme , signaling cytokine
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • NADH ubiquinone oxidoreductase (Q reductase)
  • is an essential component for the stability and activity of complex I
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component beta 8, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
  • involved in the transfer of electrons from NADH to the respiratory chain
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFB8D
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS