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FLASH GENE
Symbol TRAF1 contributors: mct/npt/pgu - updated : 05-03-2016
HGNC name TNF receptor-associated factor 1
HGNC id 12031
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal stretch of zinc finger
  • a (coiled coil) leucine zipper domains
  • a C terminal TRAF domain, (TRAF1-(164-416), required for self association (dimerization) and receptor binding
  • HOMOLOGY
    Homologene
    FAMILY
  • TRAF family
  • CATEGORY adaptor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducible molecule taking part in the signal transduction of TNFR2 (TNFRSF1B),LTBR, CD40,(TNFRSF5, CD30 (TNFRSF8, LMP1
  • involved in the blockage of apoptotic pathway
  • regulates CD40-induced TRAF2-mediated NF-kappaB activation
  • differentially affects TRAF2 recruitment and activation of NF-kappaB by members of the TNF receptor family
  • substrate of PKN1 kinase activity, and the phosphorylation event is required for attenuating downstream kinase activities
  • important molecule mediating both the TNFRSF8 signaling-dependent and independent NF-kappaB activation, which prevents the lymphoma cells from spontaneous and induced apoptosis
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homodimerizing,heterodimerizing with TRAF2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • implicated in TNFR mediated activation of NFKB and MAPK8 (JNK)
  • recruiting BIRC2,BIRC3 to TNFR2 (TNFRSF1B)
  • associating with EBV-transforming protein LMP
  • TRAF1 enhances the activation of tumor necrosis factor receptor 2 (TNFSFR1B) induced by NFKB1
  • cell & other
    REGULATION
    inhibited by inactivated by caspase during FAS ligand mediated apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hodgkin's disease and EBV, lymphoid cells
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism other a common genetic variant at the TRAF1-C5 locus is associated with an increased risk of anti-CCP-positive rheumatoid arthritis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS