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FLASH GENE
Symbol DNAH11 contributors: mct - updated : 24-01-2016
HGNC name dynein, axonemal, heavy chain 11
HGNC id 2942
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal stem binding cargo
  • a lead (motor) domain terminating in a microtubule binding site
  • HOMOLOGY
    interspecies ortholog to murine Dnahc11 (84 pc)
    Homologene
    FAMILY dynein heavy chain family
    CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • cilia in respiratory tract
  • flagella of spermatozoa
  • localizes proximally in the cilia
  • basic FUNCTION
  • outer dynein arm heavy chain having ATPase activity
  • involved in intracellular movement of organelles and vesicles or in the orientation of the mitotic spindle apparatus
  • axonemal DNAH11 assembly is independent of other axonemal dynein heavy chains such as DNAH5 and DNAH9 and that the cytoplasmic preassembly of DNAH11 is not dependent on the function of DNAAFs, such as DNAAF1 and DNAAF2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , reproduction/sex , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein tubulin
    cell & other microtubules
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inversus viscerum mouse, mutated at the outer arm dynein heavy chain 11 locus (Dnahc11) is a known model of heterotaxy