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FLASH GENE
Symbol MAFG contributors: mct/npt - updated : 04-10-2016
HGNC name v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
HGNC id 6781
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic region-leucine zipper motif through which they form homodimers or heterodimers with SLC8A1 and ACOT7 proteins
  • MAFG C terminus is required for NFE2 function, suggesting that efficient targeting of NFE2 to a specific nuclear scaffold is important to achieve high-level activity
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to avian musculoaponeurotic fibrosarcoma (v-maf) oncogene
    intraspecies homolog to mafk
    Homologene
    FAMILY
  • bZIP transcription factors family
  • Maf subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional activator by dimerzing with other basic zipper proteins
  • regulate expression and induction of detoxifying enzyme genes including quinone oxidoreductase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with NFE2 to form an erythroid and megakaryocytic cell specific transcription factor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAFG is required only for NFE2 binding to Maf recognition element (MARE) and to facilitate NFE2-mediated transcriptional activation
  • cell & other
    REGULATION
    induced by stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS