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Symbol GNGT2 contributors: mct/npt - updated : 01-06-2016
HGNC name guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
HGNC id 4412
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GGL domain
  • HOMOLOGY
    interspecies homolog to murine Gngt2
    Homologene
    FAMILY
  • G protein gamma family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a crucial role in cone phototransduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of heterotrimeric G-protein, cone transducin, comprising GNAT2, GNB3 and GNGT2 subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARRB1 (functions of ARRB1 in binding to the beta1gamma2 subunits of heterotrimeric G-proteins and promoting G(betagamma)-mediated Akt signaling for NF-kappaB activation) (Yang 2009)
  • cell & other
    REGULATION
    activated by TH (Liu 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS