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FLASH GENE
Symbol IL12RB1 contributors: mct - updated : 05-09-2017
HGNC name interleukin 12 receptor, beta 1
HGNC id 5971
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five FBN type III extracellular motifs
  • cytokine-receptor-like modules
  • conserved WSXWS motifs
  • a large cytoplasmic tail containing three tyrosine residues
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • cytokine family of receptors
  • hemopoietin receptor superfamily
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I integral transmembrane protein
    basic FUNCTION
  • coordinately regulating IFN-gamma production with antimicrobial humoral response
  • IL12RB1- and STAT3--dependent signals play likely a key role in the differentiation and/or expansion of human IL17-producing T cell populations
  • role of IL12RB1 and IL12RB2 for the expression of inducible nitric oxide synthase (iNOS) and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases
  • is essential for human resistance to multiple intracellular pathogens, including Mycobacterium tuberculosis
  • leukocytes primarily express IL12RB1 in an intracellular form located away from extracellular cytokine
  • in addition to promoting delayed type hypersensitivity (DTH), IL12RB1 also promotes autoimmunity
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • positive control
  • PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with IL12RB2
  • type I transmembrane receptor that is an essential component of the IL12- and IL23-signaling complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pairing with IL23R to form the receptor for IL23A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IL12RB1D
    related resource IL12RB1base: Mutation registry for Interleukin-12 receptor 1 deficiency
    Susceptibility
  • to tuberculosis infection
  • to atopic dermatitis
  • Variant & Polymorphism SNP
  • influencing the course of tuberculosis infection
  • polymorphisms -111A/T and -2C/T were significantly associated with an increased risk of atopic dermatitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS