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FLASH GENE
Symbol STAT4 contributors: mct - updated : 21-03-2017
HGNC name signal transducer and activator of transcription 4
HGNC id 11365
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminus conserved domain required to mediate the phosphorylation of STAT4 in addition to the previously documented role in gene transactivation
  • the coiled coil domain
  • the DNA binding domain
  • a linker region
  • a SRC homology domain 2 (SH2)
  • a critical site of tyrosine phosphorylation
  • the carboxy-terminal transactivation domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Stat4
    Homologene
    FAMILY
  • transcription factor STAT family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,chromatin/chromosome
    text translocated to the nucleus after activation
    basic FUNCTION
  • mediating responses to IL12 in lymphocytes and regulating the differentiation of T helper cells
  • STAT4 and DNMT3A play opposing roles in regulating Th1 gene expression, and one mechanism for STAT4-dependent gene programming is in establishing a derepressed genetic state susceptible to transactivation by additional fate-determining transcription factors
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    IL12
    a component
  • homodimerizing or heterodimerizing with other STAT proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STAT2 and STAT4 are direct targets for POU2F1 protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS