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FLASH GENE
Symbol SRSF5 contributors: mct - updated : 20-02-2015
HGNC name splicing factor, arginine/serine-rich 5
HGNC id 10787
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • alternative pre m-RNA splicing factor containing one N terminal RNP (RRM) motif
  • a region of homology to RRH
  • a C terminal RS domain
  • HOMOLOGY
    Homologene
    FAMILY
  • splicing factor SR family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • mediating protein-protein interaction within the intron during spliceosome assembly
  • independently binding to exonic enhancer sequences and recruiting components to adjacent introns for splice-site recognition and alternative splicing
  • regulates the splicing of CREM via its interactions with multiple ESE (exon splicing enhancers) motifs present in the alternatively exons of CREM
  • SRSF5 and SRSF6, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text mRNA
    PATHWAY
    metabolism
    signaling
    a component
  • the E commitment complex of the spliceosome assembly pattern
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by PNN, that induces reduced expression of SRSF5
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    SRSF5-CCAR1 axis may be valuable targets for cancer therapeutics
    ANIMAL & CELL MODELS