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FLASH GENE
Symbol TSN contributors: mct - updated : 30-12-2015
HGNC name translin
HGNC id 12379
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DNA binding domain formed in the ring-shaped structure in combination with its basic region
  • a functional nuclear export signal
  • secondary structure
  • asymmetric octamer barrel consisting of six translin and two TSNAX subunits
  • mono polymer homomer , heteromer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Tb-Rbp
    Homologene
    FAMILY
    CATEGORY DNA associated , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • control of recombination at d(GT)n, d(AC)n microsatellites and maintenance of telomeres
  • dimerizing DNA binding protein at the breakpoint junctions in chromosomal translocations
  • may be involved in the control of recombination at d(GT)n.d(AC)n microsatellites and in telomere maintenance
  • is a key activator of the core RNAi machinery
  • TSN and TSNAX play a central and important role in eukaryotic cell biology
  • functions as an octamer, but in the octameric crystallographic structure, the residues responsible for nucleic acid binding are not accessible
  • single-stranded DNA (ssDNA)/RNA binding protein, likely involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation
  • CELLULAR PROCESS nucleotide, recombination
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with TSNAX and associated TSNAXIP1
    INTERACTION
    DNA single stranded microsatellitesrepeats d(GT)n, telomeric repeats
    RNA binding
    small molecule
    protein
  • interaction with TSNAX (the subcellular locations of TSN and TSNAX in male germ cells are modulated by the relative ratios of TSNAX and TSN)
  • RNF139 is a target of Translin (TSN), a posttranscriptional regulator of genes transcribed by the transcription factor CREM-tau in postmeiotic male germ cells
  • TSN and TSNAX play a central and important role in eukaryotic cell biology
  • can bind single-stranded sequences internally embedded in dsDNA molecules
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS