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FLASH GENE
Symbol SLC25A6 contributors: mct - updated : 31-03-2020
HGNC name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
HGNC id 10992
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three tandemly repeated mitochondrial carrier protein domains
  • three Solcar repeats
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chicken slc25a5
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • adenine nucleotide translocator 3, ADP/ATP translocase
  • has a potential role in Th cell survival and immune cell homeostasis
  • is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis
  • plays a contributive role in camptothecin (CPT)-induced apoptosis through induction of mitochondrial permeability transition pore (MPTP)
  • export the ATP produced by oxidative phosphorylation (OxPhos) from the mitochondria into the cytosol while importing ADP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of oxidative phosphorylation (OXPHOS)
  • complexing with cyclophilin D (PPID) and adenine nucleotide translocases (SLC25A4, SLC25A5) at the inner mitochondrial permeability transition pore
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC25A6 is a previously unknown HSPA9 substrate and cell survival/death effector
  • HSPA9 facilitates BRAF-mutant tumor cell survival by suppressing SLC25A6-mediated mitochondrial membrane permeability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    decreased cellular ATP levels, limited cell growth and induced a stress-like response
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS