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FLASH GENE
Symbol HOXC4 contributors: mct - updated : 20-01-2016
HGNC name homeobox C4
HGNC id 5126
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Antp-type hexapeptide motif
  • an homeobox DNA-binding domain
  • HOMOLOGY
    interspecies homolog to rattus Hoxc4 (99.2 pc)
    homolog to murine Hoxc4 (99.6 pc)
    Homologene
    FAMILY
  • antp homeobox family
  • deformed subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in a developmental regulatory system providing cells with specific positional identities on the anterior-posterior axis
  • playing a role in regulation of transcription
  • controling lymphocyte activation and/or proliferation (Meazza 95)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • anterior/posterior pattern formation
  • cartilage development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to ATTT elements (SREs) in the Igamma and I epsilon promoters (Schaffer 2003)
    RNA
    small molecule
    protein
  • NFKB1 mediates TNFSF13-induced HOXC4 transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS