SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm
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| intracellular,nuclear envelope
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| trans-Golgi network and in protrusions in plama membrane |
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with CALCOCO2 and TAX1BP1 are present at the trans side of the Golgi complex, and on vesicles in the perinuclear region |
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myosin VI and OPTN colocalize with secretory vesicles at the plasma membrane |
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in prophase, recruited to the spindle poles and in cytokinesis, is targeted to the walls of the ingressing cleavage furrow, with a dramatic concentration in the midbody region |
basic FUNCTION
| unconventional, required for structural integrity and stereocilia function of inner hair cells |
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processive motor contractile protein moving in the reverse direction, toward the "minus" end of actin track, apparently non filamentous |
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vesicle transportering other cell types |
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required for the efficient transportation of nascent endocytic vesicles from the actin-rich peripheries of epithelial cells, allowing for timely fusion of endocytic vesicles with the early endosome |
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plays important roles in endocytic and exocytic membrane-trafficking pathways in cells |
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has novel functions in mitosis and it plays an essential role in targeted membrane transport during cytokinesis |
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with PTPRQ form a complex that dynamically maintains the organization of the cell surface coat at the stereocilia base and helps maintain the structure of the overall stereocilia bundle |
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involved in a wide range of endocytic and exocytic membrane trafficking pathways (involvement of myosin VI in this pathway |
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essential roles at the inner hair cells ribbon synapse, in addition to that proposed in membrane turnover and anchoring at the apical surface of the hair cells |
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actin-based molecular motor involved in clathrin-mediated endocytosis |
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plays potentially a key role in endocytosis-mediated protein absorption in the kidney proximal tubule |
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role for myosin VI and optineurin in regulation of fusion pores formed between secretory vesicles and the plasma membrane during the final stages of secretion |
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involved in the regulated trafficking of NHE3 and SLC34A2 between the brush border membrane and endosome ( |
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